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Human Factor XI

Catalogue Number: HFXI 1111
Size: 0.1 mg

Prepared from fresh frozen human plasma. Human Factor XI is a glycoprotein of molecular weight 160,000. This protein migrates as a single band on 6 % SDS-PAGE gels in the absence of reducing agents. Human Factor XI is comprised of two identical polypeptide chains linked by disulphide bonds which yield a single band at 80,000 upon reduction with 2-mercaptoethanol. The specific clotting activity of purified Human Factor XI is 180-200 units/mg. In vivo, Factor XI is activated to Factor XIa by Factor XIIa. The resulting Human Factor XIa consists of two heavy and two light chains held together by disulphide bridges.

Buffer Composition = 2 mM Sodium Acetate-HCl / 0.0.75 M NaCl / 50% (v/v) Glycerol / pH 5.3

Extinction Coefficient (1 %) = 13.1

Molecular Weight = 160,000 daltons

 

Supplied in LIQUID form. Shipped on ice packs.

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