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Human Factor XIII

Catalogue Number: HFXIII 1313
Size: 0.25 mg

Human Factor XIII is a tetramer composed of two pairs of chains held together by non-covalent bonds. After activation of the zymogen via Thrombin to its active enzyme form, Factor XIIIa is responsible for catalyzing the formation of covalent bridges between fibrin units to increase the elasticity of the clot network. The resulting cross-linked fibrin is very insoluble and resistant to lysis. Enzyme Research Laboratories offers the zymogen form of Human Factor XIII (a2b2).

Buffer Composition = 50 mM Tris-HCl / 0.1 M NaCl / 1 mM EDTA / 10u/ml Trasylol / 20% Glycerol / pH 7.5

Extinction Coefficient (1%) = 13.8

Molecular Weight = 320,000 daltons

 

Supplied FROZEN. Shipped on dry ice.

 

References

1. Schwartz ML, Pizzo SV, Hill RL, McKee PA: Human Factor XIII from Plasma and Platelets. Molecular weights, subunit structures, proteolytic activation and cross-linking of fibrinogen and fibrin. J Biol Chem 1973 248(4): 1395-1407

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