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Single Chain High Molecular Weight Kininogen

Catalogue Number: HK 1300
Size: 1.0 mg

High Molecular Weight Kininogen (HK) is a non-enzymatic cofactor of the contact activation system. HK is thought to have two functions in the contact activation system. First, HK links Prekallikrein to a negatively charged surface thereby allowing activation of Kallikrein by surface bound Factor a-XIIa. HK also forms a complex with Factor XI and accelerates its activation to XIa by a-XIIa. Additionally HK serves as a source of Bradykinin, a potent vasoactive peptide important in hypotension studies. The protein purity is determined by SDS-PAGE.

Buffer Composition = 4 mM Sodium Acetate-HCl / 0.15 M NaCl / pH 5.3

Extinction Coefficient (1%) = 7.01

Molecular weight = 120,000 daltons

 

Supplied LYOPHILIZED. Shipped at ambient temperature.

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